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Tissue Matrix Booster™ (TMB™)

  • TMB is a human bone-derived technology, without an additional carrier, indicated for homologous use. It can be added to any allograft and/or be mixed with saline, blood or BMA, enhancing the osteoinductive potential and the handling characteristics.
  • TMB offers immediate access to natural growth factors found in human bone and helps assist allograft placement/shape during surgical placement.
  • Surgeons report excellent handling characteristics and reduced processing time compared to leading alternatives such as Infuse® and Augment®. Available in multiple sizes.

TMB™ is a platform technology

  • TMB can boost any allograft, creating a range of ready-to-use products with superior characteristics.
  • On-going product development is focused on specific applications where pre-clinical studies demonstrated increased efficacy and efficiency at par with autograft performance.

TMB addresses an unmet need

Current standard of care

Today’s products are not well fitted to treat all patients with compromised bone healing

TMB adds to the standard of care

TMB is designed for all patients with compromised bone healing

Recombinant solutions are used off-label for a variety of indications

TMB addresses each clinical use as a bone graft substitute product

Current DBM products do not have instant access to natural human growth factors

Autograft may not be an option in patients with compromised bone healing

TMB gives instant access to natural human growth factors

TMB can enhance any existing allograft available today

TMB addresses an unmet need

Current standard of care

Today’s products are not well fitted to treat all patients with compromised bone healing

Recombinant solutions are used off-label for a variety of indications

Current DBM products do not have instant access to natural human growth factors

Autograft may not be an option in patients with compromised bone healing

TMB adds to the standard of care

TMB is designed for all patients with compromised bone healing

TMB addresses each clinical use as a bone graft substitute product

TMB gives instant access to natural human growth factors

TMB can enhance any existing allograft available today

TMB current US market status

Additional Product Information

  • AATB accredited manufacturing cleanroom ISO Certified facility located in Irvine, California, USA
  • Fully qualified and validated process
  • US/EU Patent pending technology
  • Low terminal sterilization dose with a sterility assurance level (SAL) of 10-6 and 3-year shelf life

Application

  • Clinical evaluation by experienced clinicians in the foot & ankle and spinal fusion procedures. 
  • Exceptional handling characteristics leading to ease of use
  • Clinicals results at 6 months indicate TMB is a safe and effective bone graft for multiple foot and ankle surgical procedures

TMB shows high osteoinductive potential compared to alternative technologies

Removing reliance on recombinant solutions

TMB gives instant access to more natural BMPs than current alternatives

Removing reliance on recombinant solutions

TMB combination products: Allograft Portfolio (+TMB)

Ready-to-use tissue products (currently under development)

  • Fibers and cortical bone-derived DBM boosted by TMB.
  • Exhibits superior handling characteristics post rehydration.
  • Resilient in the presence of fluids, maintaining its consistency during surgical use.

TMB combination product: MBone Putty™

CaP enriched ready-to-use products (currently under development)

Product

Orthobiologic solutions with osteoinductive potential…

  • Growth factors from human donor bone (TMB)
  • Infused in synthetic Calcium Phosphate Carrier
    • Stimulus + building block component
    • Fused together in a ready-to-use carrier

Design

…with superior design…

  • Efficacy by design
  • Safety by design

Performance

…and excellent performance

  • Preliminary results of large exploratory sheep study: at par with autograft, based on micro-CT and histology data

TMB combination products: MBone Putty™

CaP enriched ready-to-use products (currently under development)

  • MBone Putty™ has instant access to growth factors and building blocks for bone.
  • Easy application in a ready-to-use syringe.
  • Will be available in multiple sizes, ranging from 1cc to 5cc.
  • Malleable to the contour of the defect and resilient in the presence of fluids.

Our Facility

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